A scanning electron microscope study of the development of free axonal sprouts at the cut ends of dorsal spinal nerve roots in the rat |
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Authors: | I. R. Duce Jane F. Reeves Dr. P. Keen |
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Affiliation: | (1) Department of Pharmacology, Medical School, University of Bristol, England;(2) Long Ashton Research Station, Long Ashton, Bristol, England;(3) Department of Pharmacology, Medical School, University Walk, BS8 1TD, Bristol, England |
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Abstract: | Summary Rat dorsal spinal nerve roots were cut and the tip on the ganglionic side of the cut was examined by scanning electron microscopy at 0, 7, 20 and 48 h after operation. Seven hours after cutting, free axonal sprouts had started to protrude from the cut end of the nerve. After 20 h the free sprouts were more profuse than at 7 h but were smaller and had a rougher surface. At both 7 and 20 h many of the sprouts consisted of a stalk 2–7 m in diameter with a bulbous end 5–20 m in diameter. A few branching sprouts were seen. At 48 h the sprouts were shrunken with a deeply furrowed surface. The significance of the surface structure of the sprouts is discussed.I.R.D. is supported by the Medical Research Council; P.K. thanks the Mental Health Trust for a project grant |
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Keywords: | Axons Scanning electron microscopy Neurones, afferent Nerve regeneration Spinal nerve roots |
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