Small animal positron emission tomography in food sciences |
| |
Authors: | R Bergmann J Pietzsch |
| |
Institution: | (1) Positron Emission Tomography Center, Institute of Bioinorganic and Radiopharmaceutical Chemistry, Research Center Rossendorf, Dresden, Germany |
| |
Abstract: | Summary. Positron emission tomography (PET) is a 3-dimensional imaging technique that has undergone tremendous developments during
the last decade. Non-invasive tracing of molecular pathways in vivo is the key capability of PET. It has become an important tool in the diagnosis of human diseases as well as in biomedical
and pharmaceutical research. In contrast to other imaging modalities, radiotracer concentrations can be determined quantitatively.
By application of appropriate tracer kinetic models, the rate constants of numerous different biological processes can be
determined. Rapid progress in PET radiochemistry has significantly increased the number of biologically important molecules
labelled with PET nuclides to target a broader range of physiologic, metabolic, and molecular pathways. Progress in PET physics
and technology strongly contributed to better scanners and image processing. In this context, dedicated high resolution scanners
for dynamic PET studies in small laboratory animals are now available. These developments represent the driving force for
the expansion of PET methodology into new areas of life sciences including food sciences. Small animal PET has a high potential
to depict physiologic processes like absorption, distribution, metabolism, elimination and interactions of biologically significant
substances, including nutrients, ‘nutriceuticals’, functional food ingredients, and foodborne toxicants. Based on present
data, potential applications of small animal PET in food sciences are discussed. |
| |
Keywords: | : Positron emission tomography – Food sciences – Small animal PET scanners – PET tracer |
本文献已被 PubMed SpringerLink 等数据库收录! |
|