Convenient synthesis of oligodeoxyribonucleotides bearing arabinofuranosyl pyrimidine derivatives and its duplex formation with complementary DNA |
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| Authors: | Ozaki Hiroaki Nakajima Kiyohiro Tatsui Kaoru Izumi Chieko Kuwahara Masayasu Sawai Hiroaki |
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| Affiliation: | Department of Chemistry, Faculty of Engineering, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan. ozaki@chem.gunma-u.ac.jp |
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| Abstract: | The oligodeoxyribonucleotides bearing 2,2'-anhydro-beta-D-arabinofuranosyluracil derivatives were synthesized and the modified residue was converted to beta-D-arabinofuranosyluracil derivatives or beta-D-arabinofuranosylisocytosine derivatives by post-synthetic modification method. The melting profiles of their ODNs with complementary DNA were studied. |
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