The effects of verapamil and ethanol on body temperature and motor coordination |
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| Authors: | J E Johnston L J Draski J C Molina R G Burright G Reynoso B A Calendrillo R L Isaacson |
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| Affiliation: | 1. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark;2. Department of Medicinal Chemistry, Institute of Pharmacology, Polish Academy of Sciences, Poland;3. Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland;1. Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 308 Harvard Street S.E., Minneapolis, Minnesota 55455;2. Small Molecule Design and Development, Lilly Research Labs, Eli Lilly and Company, Indianapolis, Indiana 46285;1. The People’s Hospital of Wuhai, Wuhai, Inner Mongolia, China;2. Baotou Medical College, Baotou, Inner Mongolia, China |
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| Abstract: | Male, adult mice of the Binghamton heterogeneous stock received one of two doses of ethanol (1.0 g/kg or 2.0 g/kg in saline) alone or in combination with the calcium (Ca2+) slow channel blocker, verapamil (5.45 mg/kg in 25% v/v ethanol in saline). Hypothermic responses and motor incoordination were assessed in terms of rectal temperatures and rotorod activity both 20 and 60 min after drug administration. Verapamil alone did not affect body temperature, but it potentiated ethanol-induced hypothermia at both post-administration test times. Both verapamil and ethanol impaired muscular coordination and these effects were additive at the two observation periods. Verapamil did not affect ethanol blood levels from 10 to 80 min after administration of the drugs. Since motor impairment was observed when verapamil was administered with only its ethanol vehicle, this suggests a powerful interactive effect between the two drugs. |
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