Synthesis, crystal structures and in vitro anti-fungal activities of two silver(I) coordination polymers with fluconazole |
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| Authors: | Lei Zhang Yun Ling |
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| Institution: | a Department of Pharmaceutical Engineering, School of Chemical Engineering, South China University of Technology, Guangzhou 510640, PR China
b College of Chemistry and Life Science, Tianjin Normal University, Tianjin 300074, PR China |
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| Abstract: | Two new polymeric silver(I)-fluconazole complexes: Ag(HFlu)(NO3)]n (1) and {Ag(HFlu)2](ClO4)}n (2), have been synthesized and structurally characterized. The crystal structure of 1 consists of infinite 1D single strand helical coordination arrays with alternative …PMPM… arrangements, which are interlinked through hydrogen bonding interactions to generate a 3D network. The shortest intrachain Ag?Ag distance bridged by HFlu ligand is 8.287(1) Å. In 2, each Ag(I) ion is coordinated by four triazole N atoms from four HFlu ligands to form a 2D coordination layer, which has a helical arrangement along the 1 0 0] direction. The results of anti-fungal studies demonstrate that both silver(I) complexes are more active in comparison to the fluconazole drug. |
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| Keywords: | Fluconazole Silver(I) complex Crystal structure Anti-fungal activity Hydrogen bonding |
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