1-Methylisocytosine as a ligand for (dien)M (M = Pt, Pd) and Pt-promoted deamination to 1-methyluracil |
| |
Authors: | Deepali Gupta |
| |
Affiliation: | Fachbereich Chemie, Universität Dortmund, Otto-Hahn-Strasse 6, 44221 Dortmund, Germany |
| |
Abstract: | 1-Methylisocytosine (1-MeIC) can be protonated at the endocyclic N(3) position (pKa of 1-MeICH+, 4.02 ± 0.04) or complexed at this position with (dien)MII (M = Pt, Pd). X-ray crystal structures of the protonated species 1 as well as the Pd (2) and Pt (3) complexes are reported, and gas phase structures of the cation 2 and 3 have been calculated by ab initio methods. These results are compared with results from X-ray crystallography. At high pH, the Pt complex 3 undergoes deamination of the exocyclic N(2)H2 group to the 1-methyluracilate complex. As compared to the situation with 1-methylcytosine (1-MeC), the accelerating effect of (dien)PtII is much less pronounced, however. |
| |
Keywords: | Isocytosine (dien)MII complexes X-ray crystallography Deamination |
本文献已被 ScienceDirect 等数据库收录! |
|