In vitro effect of a glycopeptide acting in vivo on hepatocyte cell cycle |
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| Authors: | M-N Lombard C Nadal M-J Monnot |
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| Institution: | Institut Curie, Biologie, Bt 110, Centre Universitaire, F-91405 Orsay and Embryologie Moleculiaer, Bt 445, F-91405 Orsay, France |
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| Abstract: | Abstract A factor specifically inhibiting the hepatocyte cell cycle in vivo was found to block the G1-S transition of liver cells in vitro . It proved to be non-toxic in our culture conditions, as judged by the reversibility of the effect on cell proliferation. It was not active on DNA synthesis in fibroblastic cell lines (3T3). |
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