Spliceosomal immunophilins |
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Authors: | Mesa Annia Somarelli Jason A Herrera Rene J |
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Institution: | Florida International University, Department of Biological Sciences, University Park, 11200 SW 8th Street, OE 304, Miami, FL 33199, United States. |
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Abstract: | The spliceosome is a dynamic, macromolecular complex, which removes non-protein-coding introns from pre-mRNA to form mature mRNA in a process known as splicing. This ribonucleoprotein assembly is comprised of five uridine-rich small nuclear RNAs (snRNAs) as well as over 300 proteins. In humans, several of the known proteinaceous splicing factors are members of the immunophilin superfamily. Immunophilins are peptidyl-prolyl cis-trans isomerases that catalyze the conversion of proteins from cis to trans at Xaa-Pro bonds. Our review of the data indicates that some members of this protein family are activators of spliceosomal proteins by way of folding and transport. |
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