Unusual restriction of a proliferative line reacting with influenza A and B viruses |
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Authors: | Dr. Ghyslaine Sterkers Claude Hannoun Jean Paul Levy |
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Affiliation: | 1. INSERM U.152-CNRS ERA 781, Laboratoire d'Immunologie et de Virologie des Tumeurs, H?pital Cochin, 75674, Paris Cedex 14, France 2. Unite d'Ecologie Virale, Institut Pasteur, 75724, Paris Cedex 15, France
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Abstract: | A human T-cell line, B3, has been obtained by cloning spleen cells at limiting dilutions in the presence of influenza-A-virus-infected autologous cells. B3 cells were OKT 3+4+8-, E rosetting+, Sig- and were HLA-DR (+) after stimulation and HLA-DR (-) when resting. They proliferate specifically in the presence of influenza-virus-infected cells. Remarkable is that (a) the proliferation was obtained with viruses of both A and B types and (b) only autologous cells seem to be able to present the viral antigen to B3 cells. |
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