Structure characterization of haemostatic diosgenin glycosides from paris polyphylia |
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Authors: | James CN Ma FW Lau |
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Institution: | Department of Chemistry and Chinese Medicinal Material Research Centre, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong |
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Abstract: | From Paris polyphylla var. chinensis Hare (Liliaceae), four diosgenin glycosides with haemostatic effects were isolated. The structure of the major component was elucidated by chemical and spectroscopic methods as 3-{α-L-rhamnopyranosyl(1Rha → 2Glu)]-α-L-arabinofuranosyl(1Ara → 4Glu)]-β D-glucopyranosyl}-25(R)-spirost-5-en-3β-ol. This saponin was found to be identical to three previously reported compounds to which other structures were originally assigned, namely the major component from P. polyphylla Smith, the major cytotoxic component of yunnan paiyao, and polyphyllin D from P. polyphylla grown in the Himalaya region. |
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Keywords: | Liliaceae polyphyllin D pariphyllin yunnan paiyao haemostatic and cytotoxic diosgenin glycosides |
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