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Structure and antiherpetic activity among the Tannins |
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| Authors: | Masayuki Takechi Yasuo Tanaka Manabu Takehara Gen-Ichiro Nonaka Itsuo Nishioka |
| Institution: | 1. Faculty of Pharmaceutical Sciences Kinki University, Higashiosaka, Osaka, Japan;2. Department of Microbiology, Kobe University School of Medicine, Chuoku, Kobe, Japan;3. Faculty of Pharmaceutical Sciences, Kyushu University, Higashiku, Fukuoka, Japan |
| Abstract: | In order to investigate the relationship between the antiherpetic activity and the structure of tannins, the activities of 38 such compounds were examined. The results indicate that the activities of hydrolysable tannins were dependent on the number of galloyl or hexahydroxydiphenoyl groups and those of condensed ones on the degree of condensation. On the other hand, the more active tannins were the wore cytotoxic. |
| Keywords: | Tannins antiherpetic activity structure—activity relationships galloyl group cytotoxicity tannin—protein interaction |
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