Inhibition of mushroom tyrosinase by tropolone |
| |
Authors: | Varda Kahn Andrawis Andrawis |
| |
Institution: | Department of Food Technology, Agricultural Research Organization, The Volcani Center, P.O. Box 6, Bet Dagan 50250, Israel |
| |
Abstract: | Tropolone inhibits both mono- and o-dihydroxyphenolase activity of mushroom tyrosinase. Most of the inhibition exerted by tropolone was reversed by dialysis or by excess CU2+. The data indicate that tropolone and o-dihydroxyphenols compete for binding to the copper at the active site of the enzyme. Comparison between the effectiveness of various copper chelators showed that tropolone is one of the most potent inhibitors of mushroom tyrosinase; 50% inhibition was observed with 0.4 × 10?6 M tropolone. |
| |
Keywords: | Tropolone mushroom tyrosinase inhibition |
本文献已被 ScienceDirect 等数据库收录! |