Alkaloids of stem and rootbark of Tabernaemontana dichotoma |
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| Authors: | P Perera F Sandberg TA Van Beek R Verpoorte |
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| Institution: | 1. Center of Bio-Pharmaceutical Sciences, Division of Pharmacognosy, Gorlaeus Laboratories, State University of Leiden, Leiden, The Netherlands |
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| Abstract: | During chemical investigation for compounds possessing biological activity in the stem and rootbark of Tabernaemontana dichotoma, 22 alkaloids were isolated. Ten monomeric alkaloids were identified, viz. (?)-apparicine, coronaridine, 3-oxocoronaridine, 3-ketopropylcoronaridine, 19R-heyneanine, 3-ketopropyl-19R-heyneanine, ibogamine, isomethuenine, perivine and vobasine. Two of the monomeric alkaloids isolated were new, one was identified as 3,19R-oxidocoronaridine and the other one is not yet identified. The other ten alkaloids isolated were dimeric compounds, three were identified as tabernamine, voacamine and 3′R/S-hydroxyvoacamine. Five of the dimers were new alkaloids related to tabernamine and ervahanine type structures and identified as 3′R/S-hydroxytabernamine, 3′R/S-hydroxy-N4-demethyltabernamine, N4-demethyltabernamine and 3′R/S-hydroxy-N4-demethytervahanine A and B. The remaining two alkaloids are partially characterized. |
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| Keywords: | Apocynaceae indole alkaloids new dimeric alkaloids new monomeric alkaloid Author to whom correspondence should be addressed |
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