Steryl glycosides and acyl steryl glycosides from Musa paradisiaca |
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Authors: | Shibnath Ghosal |
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Affiliation: | Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutics, Banaras Hindu University, Varanasi 221005, India |
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Abstract: | From peeled fruits of Musa paradisiaca (banana, vegetable variety), two new acyl steryl glycosides, sitoindoside-III and sitoindoside-IV, and two new steryl glycosides, sitosterol gentiobioside and sitosterol myo-inosityl-β-D-glucoside, have been isolated by gradient solvent extraction and extensive chromatography (CC, prep. TLC, GC and HPLC). The compounds have been characterized by comprehensive spectroscopic analyses (IR, 1H NMR, GC, mass spectra, [α]D) and crucial chemical transformation. Additionally, seasonal variations of the total sterols, free sterols, steryl esters, steryl glycosides and acyl steryl glycosides in the active samples of banana have been analysed. The results provide a basis for the observed fluctuations in the anti-ulcerogenic activity of the extracts, in different seasons, and the importance of appropriate formulation of the pure principles to optimize the activity. |
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Keywords: | Musaceae sterols sitosterol stigmasterol campesterol 24-ethyllophenol citrostadienol steryl esters steryl glycosides acyl steryl glycosides seasonal variations anti-ulcerogenic activity. |
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