An 18O2 study of the biosynthesis and metabolism of rishitin |
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| Authors: | Philip A Brindle Timothy Coolbear Paul J Kuhn David R Threlfall |
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| Institution: | 1. Shell Biosciences Laboratory, Sittingbourne Research Centre, Sittingbourne ME9 8AG, U.K. |
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| Abstract: | An 18O2 study has shown that the hydroxyl oxygen atoms of lubimin, rishitin and two metabolites of rishitin, 13-hydroxyrishitin and 11,12-dihydro-13 (or 12)-hydroxyrishitin, are derived from molecular oxygen. It could not be shown that the aldehyde oxygen of lubimin was derived from molecular oxygen, probably due to its exchange with the oxygen atom of water. These findings have established that mono-oxygenases are involved in all of the hydroxylation reactions and that, contrary to a previous proposal, 11,12-dihydro-13 (or 12)-hydroxyrishitin is not formed from rishitin by hydration. |
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| Keywords: | Solanaceae biosynthesis metabolism lubimin rishitin rishitin metabolites |
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