Amorphastilbol,an antimicrobial agent from Amorpha nana |
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| Authors: | Lester A Mitscher Sitaraghav Rao Gollapudi Steven Drake David S Oburn |
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| Institution: | Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66045, U.S.A. |
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| Abstract: | Bioassay-directed fractionation of Amorpha nana demonstrated that the anti Gram positive/antitubercular constituent is amorphastilbol. The chemical structure of amorphastilbol was confirmed by chemical transformation to known (Radula variabilis) dihydroamorphastilbol and its methyl ether. Inactive 3,5-dihydroxy-7,4′-dimethoxyflavone was detected in this plant for the first time and identified by interconversion with kaempferol. All compounds were evaluated in vitro for antimicrobial spectrum and potency. |
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| Keywords: | Leguminosae amorphastilbol 3 5-dihydroxy-7 4′-dimethoxyflavone antimicrobial agents chemistry bioactivity |
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