Relation between the structure of alliin analogues and their inhibitory effect on platelet aggregation |
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| Authors: | M Liakopoulou-Kyriakides |
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| Institution: | Laboratory of Organic Chemistry, Department of Chemical Engineering, Engineering School, Aristotelian University of Thessaloniki, Thessaloniki, Greece |
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| Abstract: | Alliin analogues have been synthesized and tested for their inhibitory activity on platelet aggregation. It is found that only allicin, the S-oxodiallyl disulphide, has a strong inhibitory effect, comparable to that of alliin, while all the other tested compounds do not show any inhibitory effect even at concentrations of 10?3 M. |
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| Keywords: | Alliin allicin dihydroalliin platelet aggregation inhibitors |
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