Transformation of androstane derivatives by Spirodela oligorrhiza |
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| Authors: | Elżbieta Tłomak Paweł Paweł Witold Czerwiński Antoni Siewiński |
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| Institution: | 1. Institute of Fundamental Chemistry, Agricultural Universitry, ul. Norwida 25-50-275 Wroclaw, Poland;2. Institute of Plant Physiology, Agricultural University of Wroclaw, ul. Norwida 25,50-375 Wroclaw, Poland |
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| Abstract: | Spirodela oligorrhiza (duckweed) is capable of transforming some steroids of the androstane series. Hydrolysis of the acetates of testosterone and of 3β-hydroxyandrost-5-en-17-one by this species yielded the corresponding alcohols. Further transformation of testosterone and reduction of androst-4-ene-3,17-dione indicated the interconversions of the hydroxyl-ketone function on C-17 and reduction of the Δ4-double bond to the trans-A/B system. Only a trace amount of 3β-hydroxyandrost-5-en-17-one underwent further transformations. |
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| Keywords: | duckweed biotransformation testosterone acetate androstenolone acetate testosterone androstenolone androstenedione 5α-androstanedione |
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