Enzymatic resolution and base pairing properties of D- and L-cyclohexenyl nucleic acids (CeNA) |
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Authors: | Gu Ping Schepers Guy Griebel Carsten Rozenski Jef Gais Hans-Joachim Herdewijn Piet Van Aerschot Arthur |
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Affiliation: | Laboratory for Medicinal Chemistry, Rega Institute for Medical Research, Leuven, Belgium. |
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Abstract: | An enzymatic transesterification reaction afforded large scale resolution of the cyclohexenol precursor needed for preparation of both series of CeNA building blocks. CeNA oligos of "D-like" chirality display a strong and selective interaction with RNA, while preserving RNase H activity, and therefore have potential as antisense constructs. CeNAs of opposite chirality form a self-pairing system on their own. |
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