Stimulus responsive elastin biopolymers: Applications in medicine and biotechnology |
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Authors: | Chilkoti Ashutosh Christensen Trine MacKay J Andrew |
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Institution: | Department of Biomedical Engineering, Duke University, Durham, NC 27708-0281, USA. chilkoti@duke.edu |
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Abstract: | Elastin-like polypeptides (ELPs) are artificial polypeptides, derived from Val-Pro-Gly-Xaa-Gly (VPGXG) pentapeptide repeats found in human tropoelastin, that reversibly coacervate above a critical temperature. Genetically encodable ELPs are monodisperse, stimuli responsive, and biocompatible, properties that make them attractive for drug delivery and tissue engineering. The potential of ELPs to self-assemble into nanostructures in response to environmental triggers is another interesting feature of these polypeptides that promises to lead to a host of new applications. |
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