A 1H-NMR study of the solution conformation of cyclo(GRGDSPA): conformational effects on the physiological activity. |
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| Authors: | R Mizutani I Shimada Y Ueno M Yoda H Kumagai Y Arata |
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| Institution: | Faculty of Pharmaceutical Sciences, University of Tokyo, Japan. |
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| Abstract: | Solution conformations of cyclo(GRGDSPA) have been analyzed by the use of two-dimensional proton nuclear magnetic resonance spectroscopy and the dynamical simulated annealing calculation. It has been shown that the RGDS segment in cyclo(GRGDSPA) takes a beta-turn conformation. We have concluded that this beta-turn conformation is essential for the physiological activity of cyclo(GRGDSPA). |
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