Hypoprolactinemic Action of Calcitonin and the Tuberoinfundibular Dopaminergic System |
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| Authors: | G. Clementi,F. Nicoletti,F. Patacchioli,A. Prato,F. Patti,C.E. Fiore,&dagger ,M. Matera,U. Scapagnini |
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| Affiliation: | Department of Pharmacology, University of Catania, University of Rome, ltaly;Department of Neurology, University of Catania, University of Rome, ltaly;Institute of Second Mdical Pathology, University of Catania, and Institute of Pharmacology, University of Rome, Italy |
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| Abstract: | Abstract: The effects of calcitonin on neurochemical parameters related to the tuberoinfundibular dopaminergic system have been investigated in an attempt to elucidate how calcitonin decreases serum prolactin levels. Intracerebroventricular human or salmon calcitonin injection decreases serum prolactin, medial basal hypothalamic dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) and hypophysial DA and increases hypophysial DOPAC. Results suggest that calcitonin may decrease prolactin secretion via the tuberoinfundibular dopaminergic system. |
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| Keywords: | Calcitonin Prolactin Medial basal hypothalamus Hypophysis Dopamine Dihydroxyphenylacetic acid |
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