Selenium Deficiency Mainly Influences the Gene Expressions of Antioxidative Selenoproteins in Chicken Muscles |
| |
| Authors: | Haidong Yao Wenchao Zhao Xia Zhao Ruifeng Fan Pervez Ahmed Khoso Ziwei Zhang Wei Liu Shiwen Xu |
| |
| Institution: | 1. College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People’s Republic of China
2. The Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Harbin, Heilongjiang Province, China
|
| |
| Abstract: | Dietary selenium (Se) deficiency induces muscular dystrophy in chicken, but the molecular mechanism remains unclear. The aim of the present study was to investigate the effect of dietary Se deficiency on the expressions of 25 selenoproteins. One-day-old broiler chickens were fed either an Se deficiency diet (0.033 mg Se/kg; produced in the Se-deficient area of Heilongjiang, China) or a diet supplemented with Se (as sodium selenite) at 0.2 mg/kg for 55 days. Then, the mRNA levels of 25 selenoproteins in chicken muscles were examined, and the principal component was further analyzed. The results showed that antioxidative selenoproteins especially Gpxs and Sepw1 were highly and extensively expressed than other types of selenoproteins in chicken muscles. In 25 selenoproteins, Gpxs, Txnrd2, Txnrd 3, Dio1, Dio 3, Selk, Sels, Sepw1, Selh, Sep15, Selu, Selpb, Sepp1, Selo, Sepx1, and SPS2 were downregulated (P?P?>?0.05). Se deficiency decreased the expressions of 19 selenoproteins (P?P?
|
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
