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Acute pulmonary alveolar hypoxia increases lung and plasma endothelin-1 levels in conscious rats.
Authors:G Shirakami  K Nakao  Y Saito  T Magaribuchi  M Jougasaki  M Mukoyama  H Arai  K Hosoda  S Suga  Y Ogawa
Affiliation:Department of Medicine, Kyoto University School of Medicine, Japan.
Abstract:To investigate the effect of pulmonary alveolar hypoxia on the synthesis and release of endothelin (ET)-1, ET-1-like immunoreactivity (-LI) levels of the lung and plasma were measured in conscious unrestrained rats under hypoxic conditions. Sixty-min exposure to alveolar hypoxia (10% O2 or 5% O2) increased the ET-1-LI level in the lung. The plasma ET-1-LI level in hypoxic rats also increased significantly. The increase of plasma and lung ET-1-LI levels were parallel to the severity of hypoxia. These results demonstrates that acute pulmonary alveolar hypoxia increases lung and plasma ET-1-LI levels in conscious unrestrained rats, suggesting a possible physiological or pathophysiological significance of ET in alveolar hypoxia.
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