Self-complementary regions in human albumin mRNA encode important structural regions within the human albumin protein |
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Authors: | K G Draper |
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Affiliation: | Antiviral Chemotherapy, Schering-Plough Corporation, Bloomfield, NJ 07003. |
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Abstract: | An analysis of the human albumin mRNA structure revealed a nonrandom distribution of self-complementary regions within the mRNA. The majority of these self-complementary mRNA stretches encode important structural regions of the human albumin protein. The amino acids contained within these regions of the protein exhibit a high degree of hydrophobic complementarity which could influence local protein conformation and contribute to the biological importance of the protein structures. |
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