Three new sterigmatocystin analogues from marine-derived fungus Aspergillus versicolor MF359 |
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| Authors: | Fuhang Song Biao Ren Caixia Chen Ke Yu Xinru Liu Yuhan Zhang Na Yang Hongtao He Xueting Liu Huanqin Dai Lixin Zhang |
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| Institution: | 1. Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Beijing, 100101, People’s Republic of China
2. University of Chinese Academy of Sciences, Beijing, 100049, People’s Republic of China
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| Abstract: | During the systematic screening of active compounds from marine-derived fungi, the extract of a strain of Aspergillus versicolor MF359 isolated from a marine sponge of Hymeniacidon perleve was identified for detailed chemical investigation. Three new secondary metabolites, named hemiacetal sterigmatocystin (1), acyl-hemiacetal sterigmatocystin (2), and 5-methoxydihydrosterigmatocystin (3), together with a known compound, aversin (4), were characterized. 1 represents a first structure of sterigmatocystin hemiacetal from nature. The antibacterial activities of these identified compounds were evaluated against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Bacillus subtilis, and Pseudomonas aeruginosa. Compound 3 showed activity against S. aureus and B. subtilis with MIC values of 12.5 and 3.125 μg/mL, respectively. |
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