Molecular design of artificial ribonucleases using electrostatic interaction |
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Authors: | Burakova Ekaterina A Silnikov Vladimir N |
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Affiliation: | Novosibirsk Institute of Bioorganic Chemistry, Novosibirsk, Russia. |
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Abstract: | A number of small organic ribonucleases have been synthesized with rigid polycationic structures containing an aromatic framework with two residues of bis-quaternary salts of 1,4-diazabicyclo[2.2.2]octane (DABCO) bearing various substituents. The compounds carrying positively charged groups connected via rigid linker are expected to bend the sugar-phosphate backbone and can stimulate the intramolecular phosphoester transfer reaction. |
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