Cyclic 3',5'-adenosine monophosphate in the choroid plexus: stimulation by cholera toxin. |
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Authors: | H Cramer R Hammers P Maier H Schindler |
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Institution: | Department of Neurology, University of Freiburg Hansastrasse 9, 7800 Freiburg, West Germany |
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Abstract: | Cholera toxin was found to induce high accumulations of cyclic AMP in the isolated choroid plexus of the rabbit and in the incubation medium. The accumulation showed a characteristic lag phase of at least 30 min and continued for at least 3 hours. Inactivated cholera toxin was unable to increase cyclic AMP levels. There was only a moderate effect of cholera toxin on cyclic AMP “low Km” phosphodiesterase activity in homogenates. The effect of cholera toxin on cyclic AMP levels confirms the existance of a potent cyclic AMP generating system in the choroid plexus which is activated also by β-adrenergic agonists, histamine and prostaglandin E1. |
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