| 天南星生物碱对鼠肝线粒体膜的作用 |
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| 引用本文： | 刘春梅,陈文为.天南星生物碱对鼠肝线粒体膜的作用[J].中国生物化学与分子生物学报,1989,5(5):451-455. |
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| 作者姓名： | 刘春梅 陈文为 |
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| 作者单位： | 北京中医学院 北京
(刘春梅)，北京中医学院 北京(陈文为) |
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| 摘 要： | 本文观察到天南星中两种生物碱(201与202)均有不同程度的清除超氧阴离子自由基(O_2~- )、抑制鼠肝线粒体脂质过氧化反应、异常膨胀和膜ATP酶活性,除202对膜流动性没有明显的作用外,上述各项指标202较201的作用强度更为显著。因此可以推测该生物碱具有治疗心血管疾病和肝脏病的作用。
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| 关 键 词： | 生物碱 O_2~-自由基 鼠肝线粒体 微粘度(η) 线粒体膨胀 过氧化脂质 ATP酶 天南星 |
| 收稿时间： | 1989-10-20 |
Effects of Alkaloids from Arisema Japonicum Blume on Rat Liver Mitochondrion Membrane |
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| Liu,Chun-mei Chen,Wen-wei.Effects of Alkaloids from Arisema Japonicum Blume on Rat Liver Mitochondrion Membrane[J].Chinese Journal of Biochemistry and Molecular Biology,1989,5(5):451-455. |
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| Authors: | Liu Chun-mei Chen Wen-wei |
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| Institution: | (Central Lab., Beijing College of Traditional Chinese Medicine |
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| Abstract: | The effect of two alkaloids from Arisema Japonicum Blume, 201 and 202, on the structure and function of rat liver mitochondrial membrane was studied. It was found that both alkaloids, to some extent, have the potential ability to (1) scavenge superoxide anion radical and inhibit the lipid peroxidation of rat liver homogenate(2)inhibit the abnormal swelling of mitochondria and the activity of alkaloid 202 in all observations mentioned above except in membrane microviscosity were much stronger than those of alkaloid 201. The results of the experiments indicate that the two alkaloids may be useful in treatment of cardiovascular and liver dise ases. |
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