Studies on the biosynthesis of sym-homospermidine in sandal (Santalum album L.) |
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Authors: | Ramadasan Kuttan and A N Radhakrishnan |
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Institution: | Wellcome Research Unit, Christian Medical College Hospital, Vellore-4, Tamil Nadu, India |
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Abstract: | The biosynthesis of the newly isolated polyamine, sym-homospermidine (NH(2)-CH(2)](4)-NH-CH(2)](4) -NH(2)), was studied by using radioactive amino acids. Arginine was the most effective precursor, being about 10 times as active as ornithine. Unlabelled agmatine and putrescine markedly inhibited the incorporation of (14)C]arginine into homospermidine. Similarly the incorporation of ornithine was inhibited by unlabelled arginine and putrescine. gamma-Aminobutyraldehyde, the oxidation product of putrescine, was considered to be one of the intermediates in the biosynthesis of homospermidine. The biosynthesis may involve a Schiff-base formation of putrescine with gamma-aminobutyraldehyde and subsequent reduction. A limited synthesis of spermidine also takes place under these conditions. |
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