微生物共培养在新活性化合物挖掘中的研究进展

微生物次级代谢产物结构新颖、活性多样,一直以来都是药物及其先导化合物的重要来源。但近年来在普通微生物纯培养中发现的新活性物质不断减少,重复发现逐渐增加;而微生物共培养因更加接近微生物生长的自然环境,在药物及其先导物挖掘方面发挥着越来越重要的作用。本文分析了近5年来利用真菌vs真菌、真菌vs细菌共培养挖掘新活性化合物的研究现状,以及研究中存在的问题。

Progress of microbial co-culture in new compound mining

Microbial secondary metabolites have been an important source of drugs and their leading compounds because of their novel chemical structures and various biological activities. However, in recent years, there is a high frequency of re-discovery and a low frequency of new discovery of active compounds from microbial pure culture. As microbial co-culture is closer to the natural environment of microbial growth, it plays an important role in new compound mining. Here, we review the progress of new compound mining through co-culture from fungi vs fungi and fungi vs bacteria, and the current problems of this field for future research is also mentioned.