Radioimmunoassay of total and free corticosterone in rat plasma: measurement of the effect of different doses of corticosterone |
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| Authors: | E L Sainio T Lehtola P Roininen |
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| Institution: | Department of Pharmacology and Toxicology, University of Kuopio, Finland. |
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| Abstract: | A radioimmunological method was developed for determining total and free corticosterone in rat plasma. This method was used to determine the dose-response curve of corticosterone and to measure the elimination and study the half-lives of total and free corticosterone in rat plasma with a dose of 5 mg/kg. The elimination with a dose of 5 mg/kg, when drawn on the half-logarithmic scale, formed a straight line. The half-lives for total and free corticosterone were 25 and 15 min, respectively. |
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