Protective effect of <Emphasis Type="Italic">Spirulina</Emphasis> against 4-nitroquinoline-1-oxide induced toxicity |
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Authors: | Vijaya Padma Viswanadha Siddharth Sivan Roopesh Rajendra Shenoi |
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Institution: | (1) Department of Biotechnology, Bharathiar University, Coimbatore, Tamilnadu, 641046, India;(2) Department of Biotechnology, Kongunadu Arts and Science College, GN Mills Post, Coimbatore, Tamilnadu, 641029, India |
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Abstract: | In the present study, we focused on the protective effect of Spirulina against 4-nitroquinoline-1-oxide (4NQO) induced hepato and nephrotoxicity in the experimental rats. The 4NQO administration
resulted in increased levels of hepatic and renal markers Alanine Transaminase (ALT), Aspartate Transaminase (AST), Lactate
Dehydrogenase (LDH), urea, creatinine and uric acid] in the serum of experimental animals. It also increased the oxidative
stress resulting in increased levels of the lipid peroxidation with a concomitant decline in the levels of non enzymic reduced
glutathione (GSH)] and enzymic antioxidants (Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx), and
Glutathione-S-transferase (GST)] in both liver and kidney. Oral pretreatment with aqueous extract of Spirulina prevented 4NQO induced changes in the levels of hepatic and kidney diagnostic marker enzymes in the serum of experimental
rats. It counteracted the 4NQO induced lipid peroxidation and maintained the hepatic and kidney antioxidant defense system
at near normal in both liver and kidney. The antioxidant responsiveness mediated by Spirulina may be anticipated to have biological significance in eliminating reactive free radicals that may otherwise affect normal
cell functioning and provide a scientific rationale for the use of Spirulina. |
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