Immune responses to isolated human cytomegalovirus envelope proteins. |
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| Authors: | E G ncz l, F Hudecz, J Ianacone, B Dietzschold, S Starr, S A Plotkin |
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| Affiliation: | E Gönczöl, F Hudecz, J Ianacone, B Dietzschold, S Starr, and S A Plotkin |
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| Abstract: | A group of envelope proteins of human cytomegalovirus, gA protein (L. Pereira, M. Hoffman, M. Tatsuno, and D. Dondero, Virology 139:73-86, 1984; L. Pereira, p. 383-404, in B. Roizman, ed., The herpesviruses, vol. 3, 1985), and two protein mixtures (58,000-molecular-weight [58K]-66K and 130K-66K), separated by serial columns prepared with anti-gA immunoglobulin G from sera of immunized guinea pigs, induced neutralizing antibodies and a cellular immune response in the animals. The gA is a disulfide-linked protein complex consisting of high-molecular-weight (greater than 200K), 130K-150K, and 55K-58K proteins. |
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