Pulmonary gas mixing during spontaneous breathing and at high-frequency ventilation |
| |
| Affiliation: | 1. Osaka University, 11-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan;2. Chulalongkorn University, 254 Phayathai Road, Pathumwan, Bangkok 10330, Thailand;1. State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, Beijing 100081, China;2. College of Safety and Environmental Engineering, Shandong University of Science and Technology, Qingdao 266590, China;3. Beijing Key Laboratory of Metro Fire and Passenger Transportation Safety, China Academy of Safety Science and Technology, Beijing 100012, China;4. Jiangsu Key Laboratory of Hazardous Chemicals Safety and Control, College of Safety Science and Engineering, Nanjing Tech University, Nanjing 210009, China;5. Yangtze Delta Region Academy of Beijing Institute of Technology, Jiaxing 314000, China;6. Chongqing Innovation Center, Beijing Institute of Technology, Chongqing 400044, China;1. LaSIE, University of La Rochelle, CNRS, UMR 7356, Avenue Michel Crépeau, 17042 La Rochelle Cedex 1, France;2. 4evLab, University of La Rochelle, CNRS, Electricité de France EDF, Avenue Michel Crépeau, 17042 La Rochelle Cedex 1, France;3. LMT, ENS Cachan, CNRS, Université Paris-Saclay, 61 avenue du Président Wilson, 94235 Cachan, France;4. Structural Mechanics and Coupled Systems Laboratory, Conservatoire National des Arts et Métiers, 292 rue Saint-Martin, 75141 Paris Cedex 03, France;1. Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK;2. Nuffield Division of Anaesthetics, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK;3. New College, University of Oxford, Holywell Street, Oxford, OX1 3BN, UK;4. The Queen’s College, University of Oxford, High Street, Oxford, OX1 4AW, UK |
| |
| Abstract: | This work is intended to estimate the contribution of either laminar or turbulent dispersion during spontaneous breathing on one hand, and at high-frequency pulmonary ventilation on the other. For that purpose, we performed a computer simulation of a mathematical model of gas transport in the human airways governed by a combination of axial convection and longitudinal dispersion. Calculations were carried out by incorporating two dispersion coefficients, proposed by Taylor and Scherer respectively, into the mathematical model. Moreover, computations were performed with five constant flow rates and two inert heavy (SF6) and light (He) gases to enhance the effect of mixing. It is concluded that Taylor laminar dispersion cannot play a significant role in the human airways; however, it seems that convective gas mixing with disturbed dispersion - corresponding to a regime of quasi-steady state-can account for most gas transport during spontaneous respiration and high-frequency ventilation. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
