Activity of some enzymes involved in the metabolism of polyamines in the liver of streptozotocin-diabetic rats |
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| Affiliation: | 1. Steno Diabetes Center Copenhagen, Gentofte, Denmark;2. The National Food Institute, Technical University of Denmark, Soeborg, Denmark;3. Rigshospitalet, Copenhagen, Denmark;4. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;5. Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark;6. Department of Medicine, Randers Regional Hospital, Denmark;1. Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Ave., St. Paul, MN 55108, USA;2. Department of Food, Environmental and Nutritional Sciences, Università degli Studi di Milano, via G. Celoria 2, 20133 Milan, Italy;3. USDA-ARS Western Wheat Quality Laboratory, Washington State University, E-202 Food Science & Human Nutrition Facility East, Pullman, WA 99164, USA;4. Department of Biochemistry, Science Building, University of Cape Coast, Cape Coast, Ghana |
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| Abstract: | - 1.1. The effect of diabetes on some enzymes of polyamine metabolism was studied in male rats 1–12 days after administration of streptozotocin.
- 2.2. Hepatic ornithine decarboxylase activity decreased in the first days after the administration, but increased thereafter. The decrease was not due to an alteration of the ODC-antizyme concentration, nor to a posttranslational modification catalyzed by transglutaminase.
- 3.3. S-adenosylmethionine decarboxylase and ornithine transaminase were both increased.
- 4.4. Spermicline acetyltransferase activity was practically unchanged, while its inactivating factor was markedly decreased.
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