Pharmacological characterization of dopamine-sensitive adenylate cyclase in the salivary glands of Locusta migratoria L. |
| |
| Affiliation: | 1. ERA 620, Cytophysiologie des Arthropodes, 105 Bd Raspail, 75006 Paris France;2. CNRS-INSERM de Pharmacologie-Endocrinologie, rue de la Cardonille, 34033 Montpellier Cedex, France;1. College of Chemistry, Chemical Engineering and Environment, Minnan Normal University, Zhangzhou, Fujian, 363000, China;2. Fujian Provincial Key Laboratory of Pollution Monitoring and Control, Minnan Normal University, Zhangzhou, Fujian, 363000, China;3. Fujian Key Laboratory of Separation and Analysis Science and Technology, Zhangzhou, Fujian, 363000, China;1. Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA;2. Molecular Genetics Section, National Human Genome Research Institute, USA;3. Office of the Clinical Director, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA;4. Hypertension Unit, Chaim Sheba Medical Center, Tel Aviv University, Tel-HaShomer, Israel;1. Louisiana State University AgCenter, Department of Entomology, Baton Rouge, LA 70803, USA;2. Department of Entomology, Kansas State University, Manhattan, KS 66506, USA;3. Beijing Key Laboratory for Forest Pest Control, Beijing Forestry University, Beijing 100083, China |
| |
| Abstract: | The locust (Locusta migratoria) salivary gland adenylate cyclase was stimulated by both dopamine and serotonin (6 and 5-fold stimulation respectively). Since their effects were additive, it is concluded that these neurotransmitters are acting on two discrete receptor types.The agonist and antagonist specificity profiles were very similar to those of the D1 receptor coupled with an adenylate cyclase in vertebrates. They were clearly different from those of the D2 receptor of vertebrates. No evidence for octopamine sensitive adenylate cyclase was found in the salivary glands of L. migratoria.In addition to previous electrophysiological and histological studies (House and Ginsborg, 1979) these results suggest that dopamine has a neurotransmitter function in the salivary glands of locusts and that its function is mediated by cyclic AMP. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
