neo-Clerodane diterpenoids from Ajuga: structural elucidation and biological activity |
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| Authors: | Josep Coll Yudelsy A. Tandrón |
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| Affiliation: | (1) Departament de Química Orgànica Biològica, Institut d’Investigacions Químiques i Ambientals de Barcelona “Josep Pascual Vila”, Consejo Superior de Investigaciones Científicas, J. Girona 18, Barcelona, Spain |
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| Abstract: | The presence of several types of allelochemicals has been reported from Ajuga, a Labiatae genus comprising more than 40 species of wide distribution in extratropical regions of both hemispheres. The genus is of great medicinal and economic importance and among the biological properties of the secondary metabolites, the antifeedant activity against pest insects appears to be related to the presence of neo-clerodane type diterpenes. This review focuses on the isolation and structural elucidation of this type of compounds from Ajuga species and the hemisynthetic compounds of closely related structure obtained. The reported biological activity of crude extracts and isolated diterpenes will be briefly commented. |
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| Keywords: | Labiatae Ajuga Diterpene neo-Clerodane Biological activity |
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