Immunization of cattle against Boophilus microplus using extracts derived from adult female ticks: feeding and survival of the parasite on vaccinated cattle |
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| Authors: | D H Kemp R I Agbede L A Johnston J M Gough |
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| Institution: | 1. Ministry of Education Key Laboratory for Avian Preventive Medicine, Yangzhou University, Yangzhou, Jiangsu Province, China;2. Key Laboratory of Jiangsu Preventive Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, China;3. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu Province, China;4. Department of Microbiology, Faculty of Veterinary Medicine, University of Khartoum, Khartoum North 13314, Sudan;1. Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia PA USA;2. Department of Oral and Maxillofacial Pathology/Biology, Faculty of Dental Sciences, University of Lagos, Lagos Nigeria;3. Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, University of Lagos, Lagos Nigeria;4. Department of Oral Medicine, School of Dental Medicine, University of Pennsylvania, Philadelphia PA USA;1. Agricultural Research Council-Onderstepoort Veterinary Research, Private Bag X5, Onderstepoort 0110, South Africa;2. Department of Veterinary Tropical Diseases, Veterinary Faculty, University of Pretoria, Private Bag X04, Onderstepoort 0110, South Africa;1. Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Epidemiology, Greifswald – Insel Riems, Germany;2. Institute of Veterinary Pathology at the Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany;3. Institute for Infectious Diseases and Zoonoses, Ludwig-Maximilians-Universität München, Munich, Germany;4. Clinic for Ruminants with Ambulatory and Herd Health Services at the Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Oberschleißheim, Germany;5. Department of Veterinary Medical Sciences, University of Bologna, Via Tolara di Sopra 50, Ozzano Emilia, Bologna, Italy;1. Cell and Molecular Biology Program, Michigan State University, 567 Wilson Road, East Lansing, MI, 48824, United States;2. Department of Animal Science, Michigan State University, 474 S. Shaw Lane, East Lansing, MI, 48824, United States;3. Department of Animal Sciences, University of Wisconsin-Madison,1675 Observatory Drive, Madison, WI, 53706, United States;1. Division of Parasitology, Indian Veterinary Research Institute Izatnagar, Bareilly, Uttar Pradesh 243122, India;2. Division of Pharmacology and Toxicology, Indian Veterinary Research Institute Izatnagar, Bareilly, Uttar Pradesh 243122, India;3. Division of Bacteriology and Mycology, Indian Veterinary Research Institute Izatnagar, Bareilly, Uttar Pradesh 243122, India;4. Division of Extension Education, Indian Veterinary Research Institute Izatnagar, Bareilly, Uttar Pradesh 243122, India;5. Division of Nutrition, Indian Veterinary Research Institute Izatnagar, Bareilly, Uttar Pradesh 243122, India;6. Division of Surgery Indian Veterinary Research Institute, Indian Veterinary Research Institute Bareilly, Bareilly, Uttar Pradesh 243122, India |
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| Abstract: | Kemp D. H., Agbede R. I. S., Johnston L. A. Y. and Gough J. M. 1986. Immunization of cattle against Boophilus microplus using extracts derived from adult female ticks: feeding and survival of the parasite on vaccinated cattle. International Journal for Parasitology16: 115–120. Boophilus microplus adults and larvae were observed in chambers on three European breed cattle which had been vaccinated against the tick and on three unvaccinated controls. The moulting of larve on vaccinated cattle was delayed by up to 12 h but otherwise they were unaffected. On two of the three vaccinated cattle there was progressive death of tick females throughout feeding and up to 60% of females had a damaged gut. These females either failed to engorge, or if they did, many died before egg laying. Males also suffered gut damage. In contrast, the females which survived the first day on control cattle usually completed engorgement and neither females nor males showed damaged gut. No hypertensivity reaction or serious exudation was seen at the site of tick attachment on any animals. This was in contrast to resistance acquired following repeated tick infestations where hypersensitivity reactions caused rejection of attaching ticks, especially larvae, and where no gut damage occurred. Vaccination therefore produced effects which were additional to those that follow repeated infestations. Damage to tick gut was also demonstrated in vitro and a role for complement in this effect was suggested. |
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