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Synthesis and SAR of novel, potent and orally bioavailable benzimidazole inhibitors of poly(ADP-ribose) polymerase (PARP) with a quaternary methylene-amino substituent |
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| Authors: | Zhu Gui-Dong Gandhi Viraj B Gong Jianchun Thomas Sheela Luo Yan Liu Xuesong Shi Yan Klinghofer Vered Johnson Eric F Frost David Donawho Cherrie Jarvis Ken Bouska Jennifer Marsh Kennan C Rosenberg Saul H Giranda Vincent L Penning Thomas D |
| Affiliation: | aCancer Research, GPRD, Abbott Laboratories, Abbott Park, IL 60064, USA;bPreclinical Safety, GPRD, Abbott Laboratories, Abbott Park, IL 60064, USA |
| Abstract: | |
| Keywords: | PARP Poly(ADP-ribose) polymerase Inhibitor Benzimidazole Anticancer |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |