Effect of 16,16-dimethyl PGE2 on renal papillary necrosis and gastrointestinal ulcerations (gastric, duodenal, intestinal) produced in rats by mefenamic acid |
| |
| Authors: | G Elliott B A Whited A Purmalis J P Davis S O Field C Lancaster A Robert |
| |
| Institution: | 1. The New Zealand Institute for Plant & Food Research Limited, 120 Mt Albert Road, Private Bag 92169, Victoria Street West, Auckland, New Zealand;2. Centro de Investigación Básica en Psicología, Facultad de Psicología, Universidad de la República, Tristán Narvaja 1674, C.P. 11200 Montevideo, Uruguay;3. MAPP Centre for Research on Customer Relations in the Food Sector, Aarhus University, Bartholins Allé 10, 8000 Aarhus, Denmark;4. Sensometrics & Consumer Science, Instituto Polo Tecnológico de Pando, Facultad de Química, Universidad de la República, By Pass Rutas 8 y 101 s/n, C.P. 91000 Pando, Canelones, Uruguay;1. The New Zealand Institute for Plant and Food Research Limited, Mt Albert Research Centre, Private Bag 92169, Auckland 1142, New Zealand;2. TasteMatters Research & Consulting, Sydney, Australia;3. Dept. DAGRI, University of Florence, Italy;4. Friesland-Campina, Wageningen, The Netherlands;1. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China;2. Tianjin University of Science and Technology, Tianjin 300457, China;3. Pharmaceutical Experiment Center, College of Pharmacy, Yanbian University, Yanji 133002, China;4. Bengbu Medical College, Anhui 233003, China;5. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China;6. School of pharmacy, XuZhou Medical University, XuZhou 221004, China;1. Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Avenue, New York, NY, 10027, USA |
| |
| Abstract: | Mefenamic acid, given orally to rats at a single dose of 1200 mg/kg, produced renal papillary necrosis (RPN) in 63% of animals. The incidence was reduced to 27% by 16,16-dimethyl PGE2 (dmPGE2), given at an oral dose of 0.75 mg/kg t.i.d. RPN is likely to be caused by the renal prostaglandin depletion elicited by mefenamic acid, an inhibitor of prostaglandin cyclooxygenase. Substitution with dmPGE2 reduces RPN presumably by preventing the prostaglandin depletion. We conclude that the prostaglandin used is cytoprotective for the kidney. Mefenamic acid, like most nonsteroidal anti-inflammatory compounds (NOSAC), produced ulcerations of the small intestine (jejunum and ileum). These were prevented by dmPGE2 (intestinal cytoprotection). Unlike most other NOSAC, however, mefenamic acid produced duodenal ulcers in nearly all animals (80%). Of these ulcers, 88% were perforated. Twenty-five of the twenty-six animals that died had a perforated ulcer. These duodenal ulcers were also prevented by dmPGE2. Mefenamic acid-induced ulcers could be used as an experimental model for testing agents with a potential for preventing or healing duodenal ulcers. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
