Synthesis and antitumor activity of a series of 1,2-diaminocyclohexanepalladium(II) dicarboxylate complexes |
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| Institution: | 1. Department of Industrial Chemistry, Edo State University Uzairue, P.M.B. 04 Auchi, Edo State, Nigeria;2. Department of Industrial Chemistry, Madonna University Nigeria, P.M.B 05 Elele, Rivers State, Nigeria;3. Department of Polymer & Textile Engineering, Federal University of Technology Owerri, P.M.B. 1526 Owerri, Imo State, Nigeria;4. Department of Science Laboratory Technology, Imo State Polytechnic Omuma, Imo State, Nigeria.;5. Department of Pure and Applied Chemistry, University of Calabar, Calabar, Nigeria;6. Africa Centre of Excellence in Future Energies and Electrochemical Systems (ACE-FUELS), Federal University of Technology Owerri, Nigeria |
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| Abstract: | A series of complexes of the type Pd(O O(DACH)] (O O = dicarboxylate ligand, DACH = 1,2-diaminocyclohexane) has been prepared. These complexes have been characterized by elemental analysis and infrared spectroscopy. The complexes have been screened in vivo for antitumor activity against the L1210 leukemia cell line. These palladium complexes lack antitumor activity, which may be due to (1) lack of solubility and/or (2) lack of stability of the complexes in solution. |
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