Synthesis,characterization and antitumor activity of a series of N-substituted iminodiacetato(diammine) platinum(II) complexes |
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| Affiliation: | 1. Department of Physics, Arignar Anna Government Arts College, Musiri, Tiruchirappalli, 621211, India;2. Department of Physics, Holy Cross College(Autonomous), Tiruchirappalli, 620 002, India;3. Department of Studies in Chemistry, Mangalore University, Mangalagangothri, 574 199, India;1. Department of Chemistry, Sardar Vallabhbhai National Institute Technology, Surat, 395007, Gujarat, India;2. Department of Chemistry, Malaviya National Institute of Technology, Jaipur, 302017, Rajasthan, India;1. School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar 752050 India;2. Institute of Life Sciences, Bhubaneswar 751023, India;1. Chongqing Key Laboratory of Inorganic Special Functional Materials, College of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling, Chongqing 408100, PR China;2. School of Science, Beijing Technology and Business University, Beijing 100048, PR China |
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| Abstract: | A series of water-soluble N-substituted iminodiacetato (diammine)platinum(II) complexes [Pt(NRIDA)(NH3)2] have been synthesized and characterized by measurement of physical properties (conductivity and pH) and by various spectroscopic techniques (infrared, 1H and 13C{1H} nuclear magnetic resonance). The iminodiacetate ligand is coordinated to platinum through an O,N linkage. The results obtained suggest that these complexes are relatively stable for more than 24 h in aqueous solution. Preliminary in vitro and in vivo screening test for antitumor activity of these complexes against L1210 murine leukemia were performed. Many of complexes had acceptable in vitro cytotoxicity, but none displayed a significant level of in vivo antitumor efficacy. |
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