Synthesis and antitumor activity of N-substituted iminodiacetato(1,1-bis[aminomethyl]cyclohexane)platinum(II) complexes |
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| Institution: | 1. School of Material Sciences & Engineering, Henan University of Technology, Zhengzhou 450007, Henan, China;2. Department of Applied Science and technology, Politecnico di Torino, Corso duca degli Abruzzi, 24, Torino 10129, Italy;1. Department of Analytical Chemistry, Internalization Institute of Biotechnology and Toxicology, University of Madras, Chennai, Tamil Nadu, India;2. Department of Chemistry, Akal College of Basic Sciences, Eternal University, Sirmour, India;3. Department of Agriculture, Akal College of Agriculture, Eternal University, Sirmour, India;4. Department of Chemical and Biological Engineering, Gachon University, Seongnam, Gyeonggi-Do, South Korea |
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| Abstract: | A number of water-soluble N-substituted iminodiacetato(1,1-bisaminomethyl]cyclohexane)platinum(II) complexes have been synthesized, and their mode of coordination characterized by elemental analysis and infrared data. Preliminary in vitro screening test for antitumor activity of these complexes against L1210 murine leukemia cells were performed. The results indicate that these complexes have an acceptable in vitro cytotoxicity against L1210 leukemia. |
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