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Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists--Increasing selectivity over hERG |
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| Authors: | Meyers Kenneth M Kim Nicholas Méndez-Andino José L Hu X Eric Mumin Rashid N Klopfenstein Sean R Wos John A Mitchell Maria C Paris Jennifer L Ackley David C Holbert Jerry K Mittelstadt Scott W Reizes Ofer |
| Institution: | Procter & Gamble Pharmaceuticals, 8700 Mason-Montgomery Road, Mason, OH 45039, USA. |
| Abstract: | Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists with greater selectivity over hERG were identified. SAR studies addressing two distinct alternatives for structural modifications leading to improve hERG selectivity are described. |
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