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A model for the involvement of Okazaki fragments maturation in the expansion of short tandem repeats |
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| Authors: | Bellizzi D Losso M A Sgaramella V |
| Affiliation: | a Genetics Division, National Cancer Center Research Institute, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan b Laboratory of Mammalian Genetics, National Institute of Genetics, Mishima, Shizuoka-ken 411-0806, Japan c Graduate University for Advanced Studies, Hayama, Kanagawa-ken 240-0193, Japan |
| Abstract: | Mutations were accumulated with a wide variety in the p53 pseudogene of various wild mouse species and subspecies captured at different localities, as extensively observed in the exon 4 – exon 5 region. The rate of mutation accumulation in the mouse p53 pseudogene was estimated to be 1.4–2.1×10−8 mutations/bp/year, which is 20–30 times faster than that of the functional p53 and makes the dating possible for the time range of 106 years or more. From comparison of the mutation spectrum, the origin of laboratory mice was identified to one of two M. m. domesticus groups. |
| Keywords: | Murine genetics Mus musculus Tumor suppresser gene Mutation Evolution |
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