Frequency of nucleated red blood cells in maternal blood during the different gestational ages |
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Authors: | L P Shulman Owen P Phillips Elizabeth Tolley David Sammons S S Wachtel |
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Institution: | (1) Department of Obstetrics and Gynecology, University of Tennessee, Memphis, TN 38103, USA e-mail: swachtel@UTMEM1.UTMEM.edu, Tel.: +1 901 448 4905, Fax: +1 901 448 8476, US;(2) Department of Preventive Medicine,University of Tennessee, Memphis, TN 38103, USA, US;(3) BioSeparations Inc., Tucson, AZ 85719, USA, US |
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Abstract: | We wished to determine the time of pregnancy at which optimal numbers of nucleated red blood cells (NRBC) are present in maternal
blood. Because 30% of the NRBC in maternal blood are fetal, there are implications for prenatal screening and diagnosis. Samples
of whole blood were collected from each of 225 women at various times during pregnancy. The samples were processed by charge
flow separation (CFS), the NRBC enumerated, and the numbers compared on a week-to-week basis. To quantify the relationship
between week of pregnancy and actual and log-transformed numbers of NRBC recovered, Pearson product moment and Spearman correlation
coefficient were estimated for each of four CFS instruments and for the four instruments combined. When the data were analyzed,
we found no relationship between stage of pregnancy and numbers of NRBC recovered. Even after logarithmic transformation,
variability among the women, estimated by standard deviation, was large and relatively stable across the different stages
of pregnancy. The number of NRBC recoverable by CFS appears to be constant between 7 and 25 weeks.
Received: 26 August 1998 / Accepted: 26 October 1998 |
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