Including metabolite concentrations into flux balance analysis: thermodynamic realizability as a constraint on flux distributions in metabolic networks |
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Authors: | Andreas Hoppe Sabrina Hoffmann Hermann-Georg Holzhütter |
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Institution: | (1) Charit – University Medicine Berlin, Institute for Biochemistry, Universittsmedizin Berlin, Monbijoustr. 2, 10117 Berlin, Germany |
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Abstract: | Background In recent years, constrained optimization – usually referred to as flux balance analysis (FBA) – has become a widely applied
method for the computation of stationary fluxes in large-scale metabolic networks. The striking advantage of FBA as compared
to kinetic modeling is that it basically requires only knowledge of the stoichiometry of the network. On the other hand, results
of FBA are to a large degree hypothetical because the method relies on plausible but hardly provable optimality principles
that are thought to govern metabolic flux distributions. |
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Keywords: | |
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