脑梗死患者内脂素和基质金属蛋白酶-9与颈动脉粥样硬化斑块易损性的关系

目的：探讨血清内脂素（Visfatin）72．基质金属蛋白酶-9（MMP-9）水平与脑梗死患者颈动脉粥样硬化王囊￡块稳定性的关系和血清visfatin和MMP-9的相关性。方法：选择脑梗死患者70例，根据颈动脉粥样硬化斑块性质分为易损性斑块组（n=43）和非易损性斑块组（n=27），选取健康体检者30例作为对照组。测定血清Visfatin和MMP-9水平，并对二者间关系进行相关分析。结果：脑梗死伴颈动脉硬化组血清Visfatin、MMP-9水平高于正常对照组（P〈0．01）；易损性斑块组血清Visfatin和MMP．9水平高于非易损性斑块组，差异有统计学意义（P〈0．017）。外周血中的Visfatin水平与MMP-9呈正相关关系（r=0．643，P=0．000）。结论：在脑梗死患者中，血清Visfatin和MMP-9参与了颈动脉粥样硬化的病理生理过程，Visfatin和MMP-9升高可能与颈动脉粥样硬化斑块不稳定性的形成相关，Visfatin可通过调控MMP一9的分泌和活性从而改变斑块的易损性。

The Relationship of Serum Visfatin and MMP-9 with the Vulnerability of Carotid Atherosclerotic Plaque in Ischemic Cerebrovascular Disease

Objective： To explore the relationship of Visfatin and MMP-9 with the vulnerability of carotid atherosclerotic plaque and the correlation of serum Visfatin and MMP-9. Methods： According to the carotid atherosclerosis plaque vulnerability, 70 patients with cerebral infarction were divided into vulnerable plaque group （n=43） and unvulnerable plaque group （n=27）. Thirty healthy subjects were selected as controls （control group）. The levels of serum Visfatin and MMP-9 were examined, and analyse the correlation between them. Results： The level of Visfatin and MMP-9 in the Cerebral infarction associated with carotid atherosclerosis group was significantly higher than that in control group （P〈0.01）. The level of Visfatin and MMP-9 in the vulnerable plaque group was higher than that in the unvulnerable plaque group and control group （P 〈0.017）. A positive correlation was observed between the expression of Visfatin and MMP-9 in vitro （r=0.643, P=0.000）. Conclusion： The serum Visfatin and MMP-9 participated in the pathophysiological process of carotid atherosclerosis in cerebral infarction patients, it may be correlation high levels of Visfatin and MMP-9 with the formation of caotid atheroscleotic plaque instability, Visfatin may be regulate MMP-9 secretion and activity, which changes plaques vulnerability.