系统性红斑狼疮并发低T3综合征的影响因素分析

目的:探讨系统性红斑狼疮并发低T3综合征的影响因素。方法:选择2102年6月~2013年6月于我科住院的SLE女性患者60例,其中伴有低T3综合征的30例(排除具有原发性甲状腺疾病的病例),甲状腺功能正常的30例,分析和比较伴有低T3综合征的SLE患者与甲状腺功能正常的SLE患者入院时的血常规、C反应蛋白、血沉、肝功能、肾功能、补体C3、补体C4、24小时尿蛋白等实验室指标和临床特征,并通过单因素和多因素Logistic回归分析探讨系统性红斑狼疮并发低T3综合征的影响因素。结果:伴有低T3综合征的SLE患者SLEDAI积分、红细胞计数、血红蛋白、血小板、补体C3、白蛋白、谷丙转氨酶、尿素、24小时尿蛋白定量与甲状腺功能正常的SLE患者比较均有统计学差异(P0.05);Logistic回归分析显示SLEDAI积分(OR=2.194,1.045~4.606,P=0.038)、血红蛋白(OR=0.719,0.518~0.998,P=0.049)、谷丙转氨酶(OR=2.417,1.071~5.457,P=0.034)、白蛋白(OR=0.313,0.105~0.934,P=0.037)是系统性红斑狼疮并发低T3综合征的影响因素。结论:SLEDAI积分和谷丙转氨酶水平是系统性红斑狼疮并发低T3综合征的危险性因素,而血红蛋白和白蛋白水平是其保护性因素。

Analysis of the Factors Influencing Systemic Lupus Erythematosus Combined with Low Triiodothyronine Syndrome*

Objective： To investigate the factors influencing systemic lupus erythematosus （SLE） with low Iriiodothyronine （T3） syndrome. Methods： 30 SLE patients with low T3 syndrome, and 30 SLE patients with normal thyroid function were recruited. Laboratory data including blood routine, C-reactive protein （CRP）, erythrocyte sedimentation rate （ESR）, liver function, renal function, serum complement C3, serum complement CA, Urine protein quantification in 24 hours and clinical presentations were collected, and SLEDAI scores were assessed. The data were analyzed by single and multiple factors Logistic regression analysis. Results： There were significant differences on SLEDAI scores, red blood cell count, hemoglobin level, platelet count, seruna complement C3 level, serum albumin level, serum glutamate pyruvate transaminase level, urea level, urine protein quantification in 24 hours between the two groups （P〈0.05）. SLEDAI scores （OR=2.194, 1.045-4.606, P=0.038）, hemoglobin level （OR=0.719, 0.518-0.998, P--0.049）, serum glutamate pyruvate tmnsaminase level（OR=2.417, 1.071-5.457, P=0.034）, serum albumin level（OR=0.313, 0.105~0.934, P=0.037） were considered as the factors impacting SLE with low T3 syndrome. Conclusion： SLEDAI scores and serum glutamate pyruvate tmnsaminase level are the risk factors, while hemoglobin and serum albumin level are the protective factors for SLE combined with low T3 syndrome.